Teratogenic effects of Propylthiouracil on Swiss albino mice fetuses – A gross study

Background: Propylthiouracil is an antithyroid drug used to treat hyperthyroidism in pregnancy, as euthyroid state necessary for optimal pregnancy outcome. Few reports of fetal anomalies are associated with propylthiouracil use compared other drugs, having severe teratogenic profile. Aims and Objectives: The present study has been conducted divulge the profile by observing its gross effects on mice fetuses, limited data available despite extensive usage pregnancy. Materials Methods: A 100 mg/kg body weight/day was orally administered pregnant Swiss albino 6th, 7th, 8th days gestation (treated group), while distilled water given dams control group (same volume same duration). fetuses were collected, weighed, studied abnormalities after sacrificing 18th day conception. Results: In study, treated shows reduction various growth parameters (mean weight, mean crown-rump length, etc.) depicting retardation, comparison group. On examination, engorged cutaneous vessels, external hemorrhage, omphalocele also observed Conclusion: As have outcome, during first trimester must be minimum effective dose drug.